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Phase I Block (Depolarizing Block) Activation of nACh receptors causes membrane depolarization Transient, random muscle fasciculations of varying duration and intensity occur in 94% of patients (Renew, 2026) 5) Continuous membrane depolarization causes inactivation of sodium channels The muscle membrane becomes unresponsive to acetylcholine within 1-2 minutes after i.v

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This means amylin is not a competitor of insulin, it is its partner , released at the same time and in the same contexts

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