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In the case of nerve root impingement from spinal lesions, such as herniated disks, osteophytes, or later- al recess stenosis, the referred pain pattern follows a well known dermatomal distribution and is often recognized as such

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Specifically, ER is reduced whereas ER is elevated resulting in increased phosphorylation of p38 MAPK and activation of the p53 substrate protein, leading to apoptosis [90]

Schieren H, Rudolph S, Finkelstein M, Coleman P, Weissmann G