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LPS molecules may also activate GLP-1 in the gut [1]

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The study revealed a multi-pronged therapeutic action

Yet while reducing cardiovascular disease by treating high cholesterol, high blood pressure, and diabetes is standard practice, the concept of treating obesity to reduce cardiovascular complications has been hampered by the lack of evidence that lifestyle or pharmacologic interventions for overweight or obesity improve cardiovascular outcomes, said Michael Lincoff, M.D., SELECTs lead author and vice chair for research in Cleveland Clinics Department of Cardiovascular Medicine