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Ongoing research continues to explore potential effects on appetite-regulating hormones including leptin, ghrelin, and peptide YY, with preliminary data suggesting complex interactions that may contribute to sustained weight loss beyond simple caloric restriction

As mentioned above, the lPBN of the pons is heavily implicated in the aversive and non-aversive control of feeding via CGRP-expressing and non-CGRP-expressing neurons, respectively