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The next frontier is GLP-1 pills, and so far, it looks like Novo may have an early lead once again: In clinical trials, people on the pill version of Wegovy lost an average of 16.6% of their body weight after 64 weeks, compared to Eli Lillys GLP-1 pill, Foundayo, which helped patients lose 12.4% of their body weight after 72 weeks

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However, unlike a recent report where constitutive loss of IGF-1Rs specifically in the myocardium of male mice prevented age-related alterations to the heart 30 , late-life mAb treatment failed to preserve or restore these same parameters in male animals (Fig