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Notably, in erythroid cells, caspase-3 activation does not guarantee apoptosis execution, since the transcriptional factor GATA-1 essential for erythropoiesis is protected from caspase-3 by HSP70 (heat shock protein 70)

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However, if youre struggling with mast cell activation syndrome (MCAS), your mast cells are over-producing histamines whether there is a trigger or not

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