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Such a change was also found in healthy individuals which showed reduction of DNA methylation in individuals with the TT MTHFR genotype compared to subjects with CC MTHFR 29

Furthermore, CSCs establish metabolic symbiosis not only with stromal cells but also with tumor-associated immune cells and vascular endothelial cells, further enhancing their survival and therapy resistance

First, nanoparticles need to adhere to the cells and it was reported that larger surface area is likely to lead to a stronger adhesion to the cell

Sulforaphane enhances the cisplatin sensitivity through regulating DNA repair and accumulation of intracellular cisplatin in ovarian cancer cells