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The Janus kinase (JAK)/STAT3 pathway as well as the activation of STAT3 through AKT kinase and mTOR are the important insulin/IGF-1-stimulated, STAT3-mediated signaling pathways which are able to control immunosuppression, immunosenescence, and insulin resistance (Figs

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For gastrointestinal symptoms, which are the most common adverse effects, eating smaller, more frequent meals, avoiding high-fat foods, and staying well-hydrated can provide relief

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