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When necessary, oral pain medications can be administered in office

One of the most importantbut often underestimateddeterminants of oral drug therapy is the first-pass effect

After weight loss: Brain reward circuits become hyperactive in response to food cues Prefrontal cortex inhibitory control becomes less effective Dopamine signaling changes make food more rewarding These changes persist for years, possibly permanently Youre not imagining that food seems more appealing after weight loss

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