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The core cycle responsible for methylation, known as the folate-methionine cycle, relies on active forms of vitamin B12 (methylcobalamin), folate, and B6 to produce S-adenosylmethionine (SAM)

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Precise drug delivery by dendrimer nanoparticles is easily achieved by surface targeting, and folate-targeted dendrimers in particular are a relevant choice in cancer therapeutics, because cancer cells overexpress the folate receptor