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However, given the presence of GLP-1R in the ARC and the direct contact of the ARC with the circulation, it is plausible that GLP1-RAs could have a direct effect on the hypothalamus, on the proviso that GLP-1RA levels exceed physiological levels of GLP-1

3 Macrophage polarization and immunometabolism The functional states of macrophages are not only regulated by microenvironmental inflammatory signals, but are also closely associated with dynamic reprogramming of intracellular metabolic networks, thereby exhibiting a high degree of plasticity

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& Steinberg, G