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The endothelin receptors subtype A antagonists (ERAs) reduced the progression of DKD ( The administration of other hypoglycemic drugs, like glucagon-like-1 receptor agonists (GLP-1RA), decreases persistent macroalbuminuria in patients with DKD ( In the present study, we analyzed the synergistic cardiorenal protective effects of combining a RAS blocker (ramipril) with an SGLT2i (empagliflozin) and a GLP-1RA (semaglutide) in a mouse model of type 2 diabetes (db/db)