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In addition, R848-loaded mannosan decarboxylated polylactic acid nanoparticles (Man-pD-PLGA-NP@R848) can target TAMs in a mannose receptor-mediated manner and further reprogram TAMs to an anti-tumor phenotype thereby inhibiting tumor progression by reprogramming immunosuppressive TME from cold tumors to hot tumors (42)

Microbe-associated molecular patterns (MAMPs) are molecules found on bacterial surfaces (203) which interact with the immune cell receptors of the host to promote inflammation (204)

Sterility: It is nearly impossible to guarantee sterility in a home environment