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Patients are typically started on a lower dose (0.25 mg) and then gradually titrated up to the maximum dose of 2.4 mg over a period of 16 to 20 weeks

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Yes, the active ingredient is identical: tirzepatide

Thus, high GE (HGE) and high GI (HGI) neurons increase or decrease their frequency of potential actions, respectively, in response to increases in interstitial glucose from 5 to 20 mM, although these neurons are still not thoroughly characterized, and there are doubts about their physiological significance