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The final protein samples were analyzed for Zn(II) and thiolate content using PAR and DTNB (see Materials and Methods)

For BPC-157 specifically, the regulatory posture tightened in 2023, when the FDA placed BPC-157 in Category 2 of its interim 503A bulk-drug-substances list the category for substances that the agency judges to raise significant safety concerns a placement that in practice barred licensed compounding pharmacies from preparing it under that pathway

Recently, in multicenter real-world study in China, the add-on treatment with LCM for children and adult focal epilepsy led to the evident therapeutic efficacy with favorable safety [168, 169]

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