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Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine

doi: 10.1002/aur.1338 110 LvM

For research use, tirzepatide is the comparator most often used to ask the question, what does adding GIP activity contribute beyond what GLP-1 alone provides? That question is still actively being answered