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About SELECT clinical study SELECT (Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity) is a randomised, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of semaglutide 2.4 mg versus placebo as an adjunct to standard of care for the prevention of major adverse cardiac events (MACE) in people with overweight or obesity and established cardiovascular disease with no prior history of diabetes

These medications were developed to improve blood glucose control in the treatment of type 2 diabetes

Human studies were approved by the NIH Institutional Review Board, and studies with de-identified samples were performed

It also changes the way your brain responds to food cues, reducing cravings for high-fat, energy-dense foods