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Thus, arGLP-1 reduces albuminuria in patients with ESRD, but its effects on the progression of renal disease are not conclusive

Reports of gene-expression changes affecting thousands of genes at certain doses and exposure times are unusual in the peptide literature, and the interpretation has been an area where the more enthusiastic readings (the compound has broad regulatory activity across many cellular processes) and the more cautious readings (broad gene-expression effects can reflect secondary consequences and may not all be specific or mechanism-based) coexist in the discourse

Kitamura M, Kitamura S, Fujioka M, Kamijo R, Sato S, Sawayama Y, Uramatsu T, Obata Y, Mochizuki Y, Nishikido M, Sakai H, Miyazaki Y, Mukae H, Nishino T (2018) Methotrexate-induced acute kidney injury in patients with hematological malignancies: three case reports with literature review

Pulmonary protective effects of curcumin against paraquat toxicity