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GI side effects, the most reported, include nausea, vomiting, constipation, and diarrhea

These reports typically describe: Low mood or emotional flatness Reduced motivation or interest in activities Anxiety or irritability Changes in emotional responsiveness It is important to contextualise these reports within the broader patient experience

Melanin is deposited in the upper layer of the skin in form of Pheomelanin (lighter, yellowish pigment) or Eumelanin (darker pigment)

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