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All three tirzepatide doses were more effective than basal insulin both in reducing HbA 1c (mean differences ranging between 7.66 mmol/mol [0.70%] with tirzepatide 5 mg and 12.02 mmol/mol [1.09%] with tirzepatide 15 mg [ESM Fig

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In case of the particle with partially broken symmetry (iii), dark-field TEM images originating from diffraction spots 1 and 2 are also shown on the right, and demonstrate different crystallographic orientations in a single nanoparticle