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The TME of NSCLC contains a large number of TAMs which influence tumor progression and patient prognosis, and specifically, M2 TAMs were shown to induce tumor aggressiveness and proliferation in NSCLC [63, 64]

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GLP-1 is primarily synthesized and secreted by specialized enteroendocrine cells called L-cells, which are located throughout the intestinal tract but are most concentrated in the distal small intestine (ileum) and colon