semaglutide online prescription for weight loss Oral Reduces CV Events in T2DM – SOUL Trial (NEJM, Mar 2025) Relevant for: cardiology, diabetology, nephrology, internal medicine 🧪 T2DM + ASCVD/CKD 💊 Oral semaglutide 14 mg vs placebo 📉 Trial Scorecard: SOUL

Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS

In addition, 45.3% of participants on the 12 mg arm achieved at least 30% body-weight reduction

10.1007/s00210-024-03179-4 Naunyn Schmiedebergs Arch Pharmacol

Further investigation is warranted to elucidate the underlying reasons for the elevated GLP-1 expression and receptor activity observed in the BLA of the saline control group following the cessation of Exendin-4 treatment