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In simulations of integrin binding, an increase in the glycocalyx height of 4 nm was predicted to reduce integrin bound fraction by an order of magnitude (12), while simulations of fluctuating membranes predicted that nanometer-scale height displacements of proteins can significantly alter ligand-receptor binding kinetics (13)
ZhouALiZPaulWBurlinaPMocharlaRJoshiNet al
Glutathione comes in reduced and oxidized forms
If the drug was administered by mouth, the fraction that got into the blood could be determined by comparing to the same dose given directly into the blood, i.e., intravenously (IV)
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