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Untreated sleep issues particularly sleep apnea, which is common in patients with obesity can undermine even the best treatment protocols and may themselves improve meaningfully as weight loss progresses
Originally developed through groundbreaking research at Erasmus University Medical Center, FOXO4-DRI represents a targeted approach to cellular rejuvenation and has shown remarkable promise in preclinical studies for promoting healthspan and addressing age-related cellular dysfunction
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these processes lead to partial functional recovery [59] or the formation of the neural fiber connection between the central pattern generator (CPG) and interneurons in the spinal cord, which can enable rhythmic movement [60,61,62]
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