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In in vitro skin permeation studies, the cumulative skin permeation of SIN in the optimized TFSs3 formulation was 1.5 times higher than DTFS and 3 times higher than conventional liposomes

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In terms of safety outcomes, the analysis indicated a significantly higher risk of gastrointestinal adverse events, including diarrhea (RR = 1.75, 95% CI 1.10