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The combined pattern across MWM and PA therefore suggests that Streptozotocininduced diabetes most strongly affects tasks requiring sustained spatial learning and shortterm aversive memory, whereas Retatrutide preserves overall behavioural performance across both paradigms, albeit with task and timedependent variation in effect size

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As previously mentioned, cortisol stimulates TDO, increasing the conversion of TRP to KYN and shifting metabolism toward neuroactive metabolites