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Nearly 70% of the patients achieved an A1C of less than 7%comparable to liraglutide 1.8 mg PIONEER 4 study design 1,6 In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 711 adult patients with type 2 diabetes on metformin alone or metformin with an SGLT-2i were randomized to RYBELSUS 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily

It works by suppressing appetite, promoting a feeling of fullness, and slowing the movement of food through the digestive system

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