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[62], demonstrated that G6PD mut deficient macrophages blunt oxidative stress and proinflammatory responses, potentially leading to lower tissue inflammation especially in high fat-fed G6PD-deficient mice [51]

Injecting rats with selenium 24 hours prior to acetaminophen overdose provided significant protection against hepatotoxicity, lowered levels of ALT and AST (markers of liver damage), and increased liver glutathione levels (Schnell 1988)

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It increases GLUT4 translocation to cell membranes, improving glucose uptake and reducing compensatory hyperinsulinemia