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Our structure of the CDK11-cyclin L-SAP30BP complex reveals that SAP30BP in the CDK11-containing complex, MAT1 in the CDK7-containing CAK complex (PDB ID 6XBZ) 33 , and MED12 in the CDK8-containing CKM complex (PDB ID 7KPV) 50 do not share meaningful structural resemblance even though their functionscomplex assembly and enhancing CDK activityare similar (Fig