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But, if you have access to both, we would recommend the following: If your health would benefit from the higher percentage weight loss (15-20%) of Zepbound / tirzepatide, and you have not had a cardiac event, Zepbound offers modestly more weight loss with fewer side effects

Significant skin brightening typically becomes apparent after 6-8 weeks

[DOI] [PMC free article] [PubMed] [Google Scholar] Pearce A, Sharp L, Hanly P, Barchuk A, Bray F, de Camargo Cancela M, Gupta P, Meheus F, Qiao Y-L, Sitas F, Wang S-M, Soerjomataram I, 2018

Protocol 3: long-term maintenance (for persistent mild symptoms) Goal: Comfortable long-term adherence with minimal GI disruption