When oxidative stress is high, hormone signaling can become imbalanced, and the environment needed for fertilization, implantation, and early pregnancy becomes less stable
For example, an in-depth analysis of 10 clinical studies showed that L-carnitine can considerably reduce diastolic blood pressure, especially in overweight or obese individuals
These FAHFAs can be stored as TAGs (156) and mobilized during cold exposure by PNPLA2 to promote de-novo lipogenesis and FA-esterification in an insulin-independent manner (157), possibly explaining the coupling of lipolysis to lipogenesis in adipocytes (151)
However, a 2024 study published in Obesity recommends an evidence-based approach centered on a healthy dietary pattern that includes vegetables, fruits, whole grains, lean proteins, low-fat dairy, and healthy fats