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Li BZ, Guo B, Zhang HY, Liu J, Tao SS, Pan HF, et al

And heres where it gets more interesting NNMT is hyperactive in conditions like obesity & type 2 diabetes, Alzheimers & Parkinsons disease, aging in general

Brain 134 , 32223235 (2011)

Manganese (Mn) Manganese primarily functions as a cofactor for the mitochondrial form of superoxide dismutase (Mn-SOD), offering specialized protection to the mitochondriathe cellular powerhouses where significant oxidative stress occurs during energy production