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PPIs have come to replace histamine H 2 -receptor antagonists as the first-line treatment for conditions such as gastroesophageal reflux disease (GERD) 2 , acid-related diseases, erosive gastritis, gastrointestinal strictures and Barretts oesophagus as well as in efforts to prevent gastrointestinal bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids 2,3

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The final stage of healing remodeling begins weeks after the onset of the damage