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It is reported that 17-estradiol (E2) could suppress the TGF1-induced myofibroblast transformation and reduce the collagen production by inhibiting the TGF-1/SMAD and Rho/RhoA signaling pathway ( On the other hand, the role of adenosine receptors in transformation from fibroblast to myofibroblast in PD was investigated recently

Absolute muscle strength was unchanged throughout the study, and body weight was decreased in the active treatment groups compared with placebo

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