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B12 injections are medically indicated for individuals with a diagnosed B12 deficiency or conditions that impair B12 absorption, such as pernicious anemia, Crohns disease, celiac disease, or a history of gastric bypass surgery
GR-C3 has the highest in vitro transactivation activity of all translational isoforms, which is thought to be mediated by the absence of amino acids 197, leading to enhanced recruitment of co-activators to the AF-1 domain (31)
Sanz-Motilva V, Nagore E, Martorell-Calatayud A
10.1038/nature10939 [DOI] [PMC free article] [PubMed] [Google Scholar] Xiang B., Yu G
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