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Perturbations in the gut microbiome (e.g., the imbalance between harmful and protective bacteria) or dysbiosis characterised by, for instance, reduced diversity of short-chain fatty acids (SCFAs) producers and enriched proinflammatory microbes (e.g., H 2 S producers) is said to be responsible for the pathogenesis of IBD, and it is reviewed elsewhere (Kaur et al., 2011

Such symptoms are typically most pronounced at the beginning of treatment and tend to decrease over time as the body adjusts to the medication

it cut every bit of appetite

Astaxanthin can supplement these effects by protecting the proteins of the extracellular matrix, particularly collagen and elastin fibers, against alterations caused by oxidative stress