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However, a set of challenges impede delivering peptides to the brain, including low metabolic stability and poor penetration of the blood-brain barrier

doi:10.1038/sj.ijo.0801740

Furthermore, while GABAAR currents are increased by barbiturates (and other general anesthetics), barbiturates, as relatively non-selective compounds, bind to an entire superfamily of ligand-gated ion channels and can block ligand-gated ion channels predominantly permeable for cationic ions, the neuronal nicotinic acetylcholine receptor (nAChR), the 5-HT3 receptor, the glycine receptor, and others [231,232]

Efficacy analysis and prognostic impact of sivelestat sodium in coronavirus disease 2019-related acute respiratory distress syndrome