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The mechanism of action includes binding to the GHS-R1a receptor, activation of the Gq/11 protein-dependent signaling pathway and an increase in the intracellular concentration of calcium ions in somatotropes
Although the enzymes of the pathway are found at multiple locations within the cell, there is as yet little convincing evidence that they operate in the apoplastic space (Foyer and Kunert 2024)
Animal experiments All in vivo procedures were conducted according to the guidelines from the regional Ethics Committee for Animal Research, Skane, Sweden (permit nos
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