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Atmospheric oxygen converts reduced glutathione (left) to oxidized glutathione (right)

in diabetic rodents, Fan and colleagues [77] demonstrated that intravitreal exedin-4 injection reduced retinal cell loss, maintained Bcl-2/Bax ratios, whose imbalance is associated with retinal cell apoptosis, prevented activation of pro-apoptotic AKT, and prevented excess reactive gliosis