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The rest plateau again or dont respond

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By orchestrating coordinated changes in adipocyte lipid handling, mitochondrial biogenesis, beige adipocyte programming, adipokine secretion, immune cell composition, and extracellular matrix (ECM) dynamics, semaglutide can induce a profound functional remodeling of adipose tissue toward a more oxidative, insulin-sensitive, and metabolically flexible phenotype [11,14,62,63,64]