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Figure 4 Dihexa otoprotection is mediated by HGF/c-Met signaling We used the pharmacological inhibitor 6-AH to investigate if the observed protection conferred by Dihexa is actually mediated by HGF/c-Met signaling

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In addition to acquired causes, inherited defects in enzymes such as glutathione synthetase [73, 74] and 5-oxoprolinase result in markedly elevated pyroglutamate levels due to impaired glutathione synthesis