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Intermediate metabolites in the TCA cycle, such as alpha-ketoglutarate, oxaloacetate, succinate, and malate, can effectively replace glutamine and induce ferroptosis

Surprisingly, compared with the CM from the vector adipocytes, CM from the CPT2KD adipocytes remarkably upregulated the mRNA expression of pro-inflammatory macrophage markers in BMDMs, whereas CM from the SIRT3OE-CPT2KD adipocytes partially reversed these changes (Fig