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However, human studies showed that improvements in pain are predominantly attributed to weight loss, rather than direct analgesic effects in the condition of osteoarthritis [47]

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Here's what current guidance says: Stop Zepbound at least 12 months before trying to conceive to allow the medication to fully clear your system Use reliable contraception until you are actively trying weight loss may restore fertility unexpectedly If you become pregnant while on Zepbound, stop immediately and contact your provider If you have PCOS and are using Zepbound while planning to conceive, work with your gynecologist and endocrinologist together on a transition plan Breastfeeding There is currently no human data on tirzepatide and breastfeeding