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For 80%-90% of people with systemic mastocytosis, a mutation in the KIT gene is the cause

Numerous clinical trials, including rigorous randomized placebo-matched control studies, have all failed to show any positive clinical benefit for NSAIDs over placebo for the management of wide- spread pain associated with FMS.7 Even the corticosteroids such as prednisone show no better results than placebo when given to FMS patients.6 Based on these studies, it appears that gross soft-tissue inflammation does not play a major role in the pathogenesis of FMS

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This often leads to "clicky" joints, lower back pain, or hip discomfort