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As indicated in the Introduction, there are four possible mechanisms of GST enzyme involvement in neonicotinoid detoxification: (1) conjugating GSH with imidacloprid, (2) conjugating phase I metabolites of imidacloprid, (3) negating oxidative stress caused by imidacloprid toxicity or metabolism, and (4) a combination of these mechanisms

Farkas, O., Lifshitz, J

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

Arsenic is a heavy metal with multiple toxic effects in the body including carcinogenesis, goiter, diabetes, skin diseases, and damage to the liver, kidney, and the cardiovascular, nervous, and endocrine systems