surmount 4 tirzepatide

surmount 4 tirzepatide SURMOUNT-4 results just published in @JAMA_current 🛑Stopping #tirzepatide leads to regain of the majority of the lost weight. Is this a surprising result ⁉️ No #Obesity is a chronic disease and requires Thinking about stopping a GLP-1

Name: surmount 4 tirzepatide SURMOUNT-4 results just published in @JAMA_current 🛑Stopping #tirzepatide leads to regain of the majority of the lost weight. Is this a surprising result ⁉️ No #Obesity is a chronic disease and requires Thinking about stopping a GLP-1
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10.1107/s2052252524007784 102 ChiZ.ChenX.HoltzJ

The STEP trials evaluated higher-dose semaglutide (2.4 mg weekly) for weight management

ChREBP was down-regulated in patients with NAFLD ( n = 22) compared to healthy controls ( n = 10), and instead, SREBP1c was reported to be one of the predominant regulators of DNL in NAFLD, upregulating genes coding for ACC1 and FAS [53]

One practical note: zinc competes with copper for absorption, so if youre taking zinc daily for an extended period, a supplement that includes a small amount of copper (around 1mg to 2mg) is worth considering