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Clinical data suggests that GIP co-activation with GLP-1 may also reduce nausea rates compared to GLP-1 stimulation alone, which could explain why Retatrutide and Tirzepatide cause less nausea than Semaglutide despite being more potent compounds

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Visceral fat, the fat stored deep in the abdomen around vital organs, plays a major role in: Chronic inflammation Insulin resistance Elevated blood pressure And arterial stiffening Reducing visceral fat improves how blood vessels function and lowers strain on the heart

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