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Circ Res 118(1):145156

Additionally, L-Carnitine: Buffers acetyl-CoA buildup during high-fat metabolism Mitigates toxic acyl-CoA accumulation in metabolic diseases Scavenges free radicals and chelates metal ions (antioxidant role) Regulates membrane fluidity and stabilizes mitochondrial membranes Modulates fatty acid oxidation enzymes via PPAR pathways Carnitine deficiency is linked to mitochondrial dysfunction, muscle weakness, and lipid accumulation

Lancet 2:512-514, 1966

However, improvements in insulin sensitivity were observed only in CR-fed mice, demonstrating that as previously shown in wild-type mice, CR-induced improvements in insulin sensitivity require fasting (Fig