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Several medications have entered phase 2 or 3 of clinical trials for PWS patients ( and this therapeutic approach of appetite modulation via the hypothalamus could provide promising results not only in PWS patients, but also for patients with other types of hypothalamic obesity

The behavioral phenotype of PTZ-induced seizures was manually quantified from the recorded video analysis, using a standardized staged analysis model as shown in Table 1 (Mussulini et al., 2013)

Its defined structure and stability make it suitable for in-vitro and preclinical research models where reproducibility and consistency are essential