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Given that TNF- and IL6 have been demonstrated to enhance ceramide production [36, 37], we propose that senescent granulosa cells may contribute to ceramide accumulation through autocrine or paracrine secretion of TNF- and IL6

After reconstitution Once reconstituted with bacteriostatic water, store the vial in the refrigerator at 2 to 8 degrees Celsius

Proline is a non-essential amino acid required for protein biosynthesis, especially the production of the extracellular matrix protein collagen, which is known to provide protective mechanisms against chemotherapy in ovarian cancer (Choi et al, 2006)